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Description

Pain reliever that’s prescribed for people with moderate to severe pain. It contains the narcotic oxycodone, an opiate analgesic medication, and acetaminophen (Tylenol), a non-narcotic pain reliever and fever reducer.

Percocet 325mg is a Schedule II drug, meaning it has a high potential for abuse, potentially leading to severe psychological or physical dependence.

Knowing how long Percocet 325mg remains in your system can help prevent an accidental overdose caused by taking your next dose of medication too soon or by interactions with other medications you’re taking.

How Long Does Percocet Stay in Your System?

Blood: Up to 24 hours

Urine: Up to four days

Saliva: Up to four days

Hair: Up to 90 days

How Long Does It Take to Feel the Effects?

Percocet is mostly known for pain relief but it also makes some people feel relaxed and even sleepy. The pain-relieving effects of Percocet can typically be felt about 20 to 30 minutes after taking the drug.

Common side effects of Percocet include:

  • Constipation
  • Nausea
  • Vomiting
  • Upset stomach
  • Drowsiness or sleepiness
  • Confusion or muddy thinking
  • Dizziness
  • Headache
  • Blurred vision
  • Itching
  • Low blood pressure
  • Slowed breathing
  • Confusion
  • Mood swings
  • Depression
  • Flushing or sweating
  • Trouble concentration
  • Problems with coordination

How Long Does Percocet Last?

The half-life of a drug is how long it takes, on average, for half of the initial dose to be metabolized and leave your system. It takes several half-lives to completely eliminate the drug from your system. Understanding the half-life of Percocet can help you avoid an overdose.

Percocet 325mg has a half-life in your blood of 3.5 hours, but that varies depending on your liver function. This means that it will take an average of 19 hours to eliminate all Percocet from your system. In urine tests, traces of Percocet can generally be detected for 48 hours, starting 2 hours after the initial dose.2
The average half-life of immediate-release oxycodone is about 3.2 hours in your bloodstream. It’s metabolized in your body into noroxymorphone and oxymorphone and passes out of your body through your urine.

For the majority of people, Percocet 325mg is out of your bloodstream within 24 hours, but it’s traceable in your saliva, urine, and hair for much longer.

Blood

In blood tests, the drug is detectable for 24 hours.

Urine

Percocet is detectable in a standard urine test for three to four days after your last dose.

Saliva

Percocet can also be detected by a saliva test for one to four days after use.

Hair

The drug can be detected in hair follicles for up to 90 days.

False Positive Testing

If you take a urine drug screen while taking Percocet 325mg, it will be positive for opioids, so let the clinic know what you’re taking ahead of time. It’s also always a good idea to disclose any drugs and supplements you are taking to the testing agency, in case they can trigger a false positive.

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